US Appeal Board Rejects Method and Program for Cluster Analysis in Bioinformatics (Ex parte Kelkar)

[part of a heat map of gene expression value; from Wikimedia] In Ex parte Kelkar, claims were directed to a method for determining similarity between portions of gene expression profiles or genes (independent claim 1) and a program product having computer readable code stored on a recordable media for determining similarity between portions of gene expression profiles or genes (independent claim 10). Illustrative claim 1 reads: 1. A method for determining similarity between portions of gene expression profiles in a computer comprising the steps of: processing a number of gene expression profiles with a similar sequences algorithm that is a time and intensity invariant correlation function to obtain a data set of gene expression profile pairs and a match fraction for each gene expression profile pair; listing gene expression profile pairs in clusters by their match fractions; removing a first gene expression profile from a cluster when another cluster has another gene expression profile with a higher match fraction with the first gene expression profile, unless the another gene expression profile requires a larger number of subsequences to achieve similarity with the first gene expression profile; repeating the removing step until all gene expression profiles are listed in only one cluster providing output of the listing of clusters of gene expression profiles. Parallel to claim 1, program product claim 10 comprises "programmed means" for each of the steps as defined by claim 1 ...Zum vollständigen Artikel


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